Formulation Optimization for Gastroretentive Drug Delivery System of Carvedilol Cocrystals Using Design of Experiment

Objectives The objective of this study was to develop a gastroretentive dosage form (GRDF) of carvedilol cocrystals that were prepared utilizing hot-melt extrusion (HME) in order to prolong its gastric residence time. GRDF was optimized using Box-Behnken Design.