ZNS-wirksame 4-Phenylpyrane: 9-Phenyl-9-piperidino-3-oxa-7-azabicyclo[3.3.1]nonan
1987
Die aus dem Oxa-azabicyclo[3,3,1]nonan 4 darstellbaren Aminonitrile 6a und 6b reagierten mit Phenylmagnesiumbromid stereoselektiv zum 9-Phenyl-9-piperidino-bicyclononan 7, bei dem zwar eine bemerkenswerte Opiatrezeptoraffinitat gefunden wurde, analgetische Eigenschaften jedoch nicht feststellbar waren.
Centrally Acting 4-Phenylpyranes: 9-Phenyl-9-piperidino-3-oxa-7-azabicyclo[3.3.1]nonane
The aminonitriles 6a and 6b were prepared from oxa-azabicyclo-[3.3.1]nonane 4. The stereoselective reaction of 6a/6b with phenylmagnesium bromide furnishes the title compound 7, which shows remarkable affinity to the opiate receptor but no analgetic effects.
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