Synthesis and evaluation of antioxidant, anti-edematogenic and antinociceptive properties of new selenium-sulfa compounds.

We describe here results for the synthesis and synthetic application of 4-amino-3-(arylselanyl)benzenesulfonamides, and preliminary evaluation of antioxidant, anti-edematogenic and antinociceptive properties. This class of compounds was synthesized in good yields by a reaction of commercially available sulfanilamide and diorganyl diselenides in the presence of 10 mol% of I 2 . Furthermore, the synthesized compound 3a was evaluated on complete Freund's adjuvant (CFA)-induced acute inflammatory pain. Dose and time-response curves of antinociceptive effect of compound 3a were performed using this experimental model. Also, compound 3a effect was tested in hot-plate test to evaluate the acute non-inflammatory antinociception. The open field test was performed to evaluate the locomotor and exploratory behaviors of mice. Oxidative stress markers, such as glutathione peroxidase activity; reactive species, non-protein thiols, and lipid peroxidation levels were performed to investigate the antioxidant action of compound 3a . Our findings suggest that the antioxidant effect of compound 3a may contribute to reducing the nociception and suppress the signaling pathways of inflammation on the local injury induced by CFA. Thus, compound 3a reduced the paw edema as well as the hyperalgesic behavior in mice, being a promising therapeutic agent for the treatment of painful conditions.