Chemotherapeutic activity of lytic enzymes in experimental staphylococcal infection

: It was shown possible to use lytic enzymes from Streptomyces recifensis subsp. lyticus 2435 for chemotherapeutic purposes. After fractionation with ammonium sulfate or chromatographic purification on sephadex G-75, the enzymatic preparations were found to be complex and contain a number of proteinases and lytic endopeptidases. They were highly active in vitro in lysing thick staphylococcal suspensions. The local use of the preparations provided a favourable therapeutic effect on a model of experimental staphylococcal infection of albino mice and rats. It was evident from rapid arrest of the inflammatory process or earlier maturation and opening of abscesses and their cicatrization. The contribution of nonlytic proteinases to the process is not excluded.