International Isotope Society. Abstracts of the Xth I.I.S. (UK Group) Symposium. Current themes in Isotopic chemistry.

The tenth annual symposium of the International Isotope Society's United Kingdom Group took place at the Alderley Park site of AstraZeneca plc. The symposium was attended by over 80 delegates from academia, the pharmaceutical and agrochemical industries, life science and fine chemical companies. Delegates were welcomed to the site by Dr Peter Warner of the Medicinal Chemistry Department. The scientific programme consisted of presentations on isotopic chemistry and applications of labelled compounds, or of chemistry with significant implications for isotopic synthesis. Both short-lived and long-lived isotopes were represented, as were stable isotopes. The programme was split into a morning and afternoon session chaired by Dr John Harding (AstraZeneca, who also organised the excellent domestic programme) and Dr Karl Cable (Glaxo Wellcome). The meeting ended with concluding remarks from Dr Ken Lawrie (SmithKline Beecham), chairman of the UK Group. This years symposium had a larger attendance from other European countries, an excellent level of sponsorship was achieved, and the symposium proved self-financing. The next UK group symposium is planned for early October 2001. Meeting Programme Paul Pringle [University of Bristol, UK] To what extent can Homogeneous Catalysts be Designed? Henrick Olsen [Novo Nordisk, Denmark] Mapping of Pharmaceutical Degradation Products in the Solid Dosage Form using Radiotracers. Marie-Claire Lasne [University of Caen, France] Synthesis of New Ligands of Cholinergic Receptors. Strategies for their Radiolabelling with Positron Emitters, Carbon-11 or Fluorine-18. Christopher Rayner [University of Leeds, UK] Catalysis in Supercritical Carbon Dioxide - What advantages does it have to Offer? Gunnar Antoni, [University of Uppsala, Sweden] Position Specific Labelling of Biomedically Interesting Compounds using Short-Lived Radionuclides. Hugh Wiltshire [Hoffmann-La Roche, UK] The Use of Stable-Labelled Isotopes in Bioequivalence Studies with the HIV-Protease inhibitor Saquinavir. Alison Hill [Kings College, UK] Elucidation of Soraphen A Biosynthesis using2H, 13C and18O-Labelled Precursors. Nick Shipley [Glaxo Wellcome, UK] Preparation of P450 Substrates for use in Drug-drug Interactions Andrew Mather [AstraZeneca, UK] Aspects of Isotopic Labelling by Parallel Chemistry. Helen Booth [Astra Zeneca, UK] Synthesis of14C-labelled forms of a series of Human Leukocyte Elastase Inhibitors.