Cell Structure and the Regulation of Genes Controlling Proliferation and Differentiation: The Nuclear Matrix and Cytoskeleton

In this chapter and in the one which follows we will present concepts and experimental approaches associated with the relationship of proliferation to differentiation with emphasis on the contribution of cell structure to the regulation of cell growth and tissue specific gene expression. While these relationships are of broad biological relevance, we will focus primarily on development of the osteoblast phenotype with the understanding that analogous principles apply to the regulation of phenotype expression in general.