Clinical assessment, oral and cervical cytology profile of women with cervical squamous intraepithelial lesion / Avaliação clínica e citológica da cavidade oral e da cérvice de mulheres com lesões intraepiteliais escamosas cervicais

Introduction: HPV is a DNA virus capable of infecting the skin and mucous membranes inducing cell proliferation. An exfoliative cytology as a diagnostic tool for HPV is useful in the diagnosis of several lesions, such as premalignant or malignant oral mucosa. The combination of the use of specific brushes and the liquid based is a potential method for early detection of injuries both in the cervix and in the mouth. Objective: The aim of this study was to evaluate the frequency of clinical and cytological changes in the oral cavity of women with cervical squamous intraepithelial neoplasms (NIC). Material and methods: Sample was divided into case group (G-NIC) (women with squamous cervical intraepithelial lesions) and control group (CG) (women without changes suggestive of high-grade lesions). Women were evaluated for the presence of oral or cervical lesions. A liquid based exfoliative cytology was collected from both regions, were submitted to Papanicolaou staining and classified according to the Bethesda system. 98 women were evaluated, G-NIC=59 and CG=39. Results: The frequency of oral lesions was G-NIC=6.6% and CG=7.5%. They were inflammatory lesions, lichen planus and soft tissue benign tumor. G-NIC oral cytology analysis: 66% negative for intraepithelial lesion and malignancy, 2% atypical squamous cells of undetermined significance and 32% had processing errors. G-NIC cervico-vaginal samples: 61% was high-grade intraepithelial lesions, 17% atypical squamous cells of undetermined significance and 22% low-grade intraepithelial lesions. CG showed 92% of oral and 82% of cervical samples was negative to intraepithelial injury and malignancy. Conclusion: There are no clinical and cytological changes in the mouth of women with intraepithelial lesions in the cervical-vaginal region.