Optical resolution of β-blockers by HPLC on cellulose triphenylcarbamate derivatives

Optical resolution of five β-adrenergic blocking agents (β-blockers) alprenolol, oxyprenolol, propranolol, pindolol, and atenolol was examined by HPLC on 13 chiral stationary phases composing of cellulose triphenylcarbamate derivatives. All β-blockers were completely resolved on a cellulose tris(3,5-dimethylphenylcarbamate) column.