Role of human antigen R in acute lung injury

Human antigen R (HuR) is widely distributed in mammals, mainly in the nucleus. HuR can bind to AU-rich elements-containing mRNAs under hypoxia, stress and ultraviolet ray stimulation,and increase the stability of target mRNAs. p38 MAPK-MK2, AMPK and PKC are involved in regulating HuR, which plays an important role in cycle regulation, proliferation, differentiation and inflammation.In acute lung inflammation, HuR can bind to the mRNAs of tumor necrosis factor-a, interleukin-19 and interleukin-8 and affect the mRNA stability and the corresponding protein production. HuR knockdown reduces the levels of mRNA and protein expression of inflammatory factors, which shows that HuR plays an important role in acute lung injury. Key words: Acute lung injury;  Human antigen R;  p38 mitogen activated protein kinase;  Interleukin-8; Interleukin-19