Improved compositions of immunosuppressive drugs for administration pulmonary administration

A composition suitable for pulmonary administration comprising: a nanostructured aggregate substantially amorphous rapid dissolution, high power, which comprendetacrolimus and a stabilizing matrix comprising optionally a polymeric or nonpolymeric surfactant or nopolimerico, a polymeric saccharide or both, wherein the aggregate comprises a greater surface area of ​​5 m2 / g measured by BET analysis and exhibesobresaturacion for at least 0.5 hours when added 11 to 15 times the solubility crystalline aqueous detacrolimus a simulated lung fluid.