Prostate-Specific Membrane Antigen Is a Potential Antiangiogenic Target in Adrenocortical Carcinoma.

Context: Adrenocortical carcinoma (ACC) is a rare tumor type with a poor prognosis and few therapeutic options. Objective: Assess prostate-specific membrane antigen (PSMA) expression as a potential novel therapeutic target for ACC. Design: Expression of PSMA was evaluated in benign and malignant adrenal tumors and 1 patient with metastatic ACC. Setting: This study took place at a tertiary referral center. Patients: Fifty adrenal samples were evaluated, including 16 normal adrenal glands, 16 adrenocortical adenomas, 15 primary ACC, and 3 ACC metastases. Main Outcome Measures: Demographics, PSMA expression levels via real-time quantitative polymerase chain reaction and immunohistochemistry and whole-body positron emission tomography-computed tomography standardized uptake values for 1 patient. Results: qPCR demonstrated an elevated level of PSMA in ACC relative to all benign tissues (P < .05). Immunohistochemistry localized PSMA expression to the neovasculature of ACC and confirmed overexpression of PSMA in...