Effect of LipoPGE1 on Sudden Deafness. Comparison with Therapy without LipoPGE1.

We studied the clinical effects of LipoPGE1 in 23 patients with sudden deafness who also received methylprednisolone (LipoPGE1 group). Twenty one patients were treated with methylprednisolone without LipoPGE1 (non-LipoPGE1 group).Complete recovery was noted in 10 patients, marked improvement in 4, improvement in 8, and no change in 1 in the LipoPGE1 group. The corresponding figures were 6, 2, 5 and 8 in the non-LipoPGE1 group.The differences were statistically significant. No serious side effects were observed in the LipoPGE1 group.These results suggest that LipoPGE1 therapy combined with steroid is effective in patients with sudden deafness.