New crystalline form of pitavastatine hemi calcium salt and the preparation thereof

2009 
PURPOSE: A method for preparing pitavastatin hemicalcium crystal salt A is provided to ensure excellent storage stability. CONSTITUTION: A method for preparing pitavastatin hemicalcium salt crystal A comprises: a step of mixing ethanol and water in a ratio of 2:1(wt/wt)~6:1(wt/wt); a step of adding pitavastatin hemicalcium salt in the mixture solvent and heating at 65-80°C; and a step of stirring the mixture at room temperature and crystallizing at 15-30°C for 5-10 hours. A pharmaceutical composition for preventing and treating hyperlipidemia contains the pitavastatin hemicalcium salt crystal A as an active ingredient.
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