Remission of Menetrier's disease associated with ranitidine administration

We describe a patient with Menetrier's disease in whom acute administration of ranitidine reduced gastric protein loss more effectively than cimetidine or propantheline. Thispatient went into remission following a course of ranitidine. We reviewed the literature on remissions in Menetrier's disease occurring without surgery. More detailed studies of various anti-secretory agents on individual patients are required to determine whether ornot they are truly efficacious.