Flavonoids from Ziziphus jujuba Mill var. spinosa

Abstract Eight flavonoid compounds were isolated from the seeds of Ziziphus jujuba Mill var. Spinosa . On the basis of chemical and spectral analyses their structures were elucidated as swertish ( 1 ), puerarin ( 2 ), 6‴-feruloylspinosin ( 3 ), apigenin-6- C -β- d -glucopyranoside ( 4 ), spinosin ( 5 ), 6‴-feruloylisospinosin ( 6 ), isospinosin ( 7 ), and isovitexin-2″- O -β- d -glucopyranoside ( 8 ). Flavonoids 6 and 7 are novel compounds. Rotamers exist for compounds 1 , 3 and 5 , which are reported for the first time. Compounds 2 , 4 and 8 were isolated from this plant for the first time. Spinosin and swertish possess significant sedative activity.