Metabolism of Cyanox, O, O-Dimethyl O-(4-Cyanophenyl) Phosphorothioate in the Rats

Orally administered Cyanox, O, O-dimethyl O-(4-Cyanophenyl) phosphorothioate, label-led with carbon-14 at p-cyano group was easily absorbed from the gastrointestinal tract of male Wistar rats, and distributed into tissues. Elimination of the radioactivity was rapid and essentially complete; namely during 96 hr approximately 90.7% and 100 of total radioactivity were excreted respectively into urine and feces. Carbon-14 in expiration was negligible. No detectable amount of Cyanox was found in the urine and 0.01% of the administered compound was present in the feces. Degradation products in the urine were identified as demethylcyanox, demethylcyanoxon, p-cyanophenol and p-cyanophenylsulfate.