Non-Invasive Predictors of Esophageal Varices in Patients with Chronic Viral Hepatitis associated with Cirrhosis Kronik Viral Hepatitlere Bağli Gelişen Siroz Hastalarinda Özefagus Varislerinin Non İnvaziv Prediktörleri

3 , Gastroenterology 4 Edirne ABSTRACT Objective: Esophageal varices that occurs as a result of portal hypertension can cause serious complications. It is known that there are some non-invasive parameters in the prediction of the presence and size of varices. In this study, non-invasive parame- ters in the prediction of the existence of varices are evaluated among the patients who have chronic liver disease which has chron- ic hepatitis B and C. Methods: Eighty-one cirrhotic patients with hepatitis B and C who applied to Gastroenterology clinics of Trakya University, Abant Izzet Baysal University and Bolu Izzet Baysal State Hospital between March 2013 - June 2014 were included in the study. The num- ber of platelets and ultrasonographic evaluation (spleen size, portal and splenic vein diameter, portal flow) was performed on ad- mission. The relationship between laboratory and radiological data and varices was analyzed. The sensitivity and specificity were calculated by ROC analysis for platelet/spleen ratio. We also assessed the significant data that can be predictors of the presence of varices by using data regression analysis. Results: Sixty-nine out of 81 patients were chronic hepatitis B related cirrhosis and 12 of them were chronic hepatitis C related cirrhosis. Twenty-eight of the patients (35%) were female and 53 of them (65%) were male. The average age was 59 (±10). Thirty- nine of the patients (48%) were child A, 25 (31%) were child B and 17 (21%) were child C. Observing the results of 69 patients with varices and 12 patients without varices, it was found that there were significant difference in Child score, platelet number, spleen size, portal vein diameter and platelet/spleen (number/mm). Among these data, it was found that only platelet number/spleen size rate can predict presence of varices (p=0.001). Conclusion: Platelet number/spleen size rate is a significant non-invasive factor in predicting of existence of varices in cirrhotic patients.