Preliminary Crystallographic Study of a Complex Formed between the α/β-Tubulin Heterodimer and the Neuronal Growth-Associated Protein SCG10

Abstract Crystals of a complex formed between the α/β-tubulin heterodimer and SCG10, a neuron-specific growth-associated protein, have been obtained by the hanging drop method. They belong to the space group P2 1 2 1 2 1 , with unit cell parameters a = 56 A, b = 353 A, c = 466 A and four molecular complexes in the asymmetric unit. A complete X-ray diffraction data set to 6.1 A resolution has been collected using synchrotron radiation. This represents a challenging opportunity to study at a molecular level the structure–function relationships between a microtubule-destabilizing protein, SCG10, and tubulin.