DISCOVERY, MECHANISM AND EXPECTED CLINICAL SIGNIFICANCE OF SELECTIVE CYTOTOXICITY OF 2-CHLORO-2'-DEOXYADENOSINE (2-CDA)

: 2-Chloro-2'-deoxyadenosine (2-CdA) is a new promising antileukemic and immusuppressive agent. Discovery of 2-CdA and its unique properties, methods of synthesis, data explaining mechanism of its selective cytotoxicity, and current clinical status of the drug are briefly reviewed.