Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness, Functional Subzones and Macular Ganglion Cell-Inner Plexiform Layer in Differentiating Patients with Mild, Moderate and Severe Open-Angle Glaucoma.

2020 
PReCIS:: Based on 6 functional subzones of peripapillary retinal nerve fiber layer (pRNFL) thickness, the glaucoma detection ability of zone 2 and zone 4 was high and comparable with that of mean pRNFL in glaucoma groups. PURPOSE To compare diagnostic performance of peripapillary retinal nerve fiber layer (pRNFL) subzones, mean pRNFL thickness and macular ganglion cell-inner plexiform layer (mGCIPL) in mild, moderate and severe open-angle glaucoma. METHODS 181 patients with open-angle glaucoma (318 eyes: 122 mild, 60 moderate and 136 severe glaucoma) and 70 normal subjects underwent spectral-domain optical coherence tomography (SD-OCT) measurements. FORUM software was used to determine subzone pRNFL thickness mapping the visual field to the optic disc (6 zones). The thickness and area under the receiver operating curve (AUROC) of each parameter was compared between groups. DeLong's method was used to compare AUROCs between mean pRNFL and mGCIPL and each zone of SD-OCT parameters. RESULTS Mean pRNFL thickness (99.81±10.06▒μm) and mGCIPL thickness (83.24±5.91▒μm) were higher in controls compared to glaucoma (67.42±13.22▒μm and 63.31±10.85▒μm; P 0.0038). CONCLUSIONS Mean pRNFL had the best diagnostic performance in mild and severe glaucoma. Glaucoma detection ability of zone 2 and zone 4 was high and comparable with that of mean pRNFL and mGCIPL in all glaucoma groups.
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