Infectious Dose And Gestation Age Influence Abortion Incidence In Mice Infected With Toxoplasma Gondii

Purpose of this study was to determine the effect of infection dose and gestation age on the incidence of abortion in mice infected with Toxoplasma gondii RI-I strain. The research was conducted in three steps. The first step, the treatment of infection was performed at 9.5 days gestations with doses of infection 10 tachyzoites of T. gondii. The second step, treatment of infection was performed at 16 days gestation with doses of infection 10 tachyzoites of T. gondii. The third step, the treatment of infection was performed at 16 days gestation with doses of infection 5 tachyzoites of T. gondii. Results showed that infection gestation at 9.5 days with a dose of 10 tachyzoites of T. gondii causes 50 percent of the parent having abortion on day 17 to day 18 followed by death. Treatment of infection was performed at 16 days gestation with doses of infection 10 tachyzoites of T. gondii, parent child-bearing mice were still with the placenta and treatment of infection at 16 days gestation with doses of infection 5 tachyzoites of T. gondii obtained all paralt childbearing. Thus on the first step, the second and third, all the parent dies 8 days after infection. Key words: Toxoplasma gondii, abortion, TNF-Œ