CellTool: an open source software combining bio-image analysis and mathematical modeling

Summary: We present CellTool, a stand-alone open source software with a Graphical User Interface for image analysis, optimized for measurement of time-lapse microscopy images. It combines data management, image processing, mathematical modeling and graphical presentation of data in a single package. Multiple image filters, segmentation and particle tracking algorithms, combined with direct visualization of the obtained results make CellTool an ideal application for rapid execution of complex tasks. In addition, the software allows for the fitting of the results to predefined or custom mathematical models. Importantly, CellTool provides a platform for easy implementation of custom image analysis packages written on a variety of programing languages. Availability and Implementation: CellTool is a free software available for MS Windows OS under the terms of the GNU General Public License. Executables and source files, supplementary information and sample data sets are freely available for download at URL: https://dnarepair.bas.bg/software/CellTool/ Supplementary information: Supplementary data are available at URL: https://dnarepair.bas.bg/software/CellTool/Program/CellTool_UserGuide.pdf