Serum triglyceride level and hypertension are highly associated with the recovery of COVID-19 patients

The coronavirus disease-19 (COVID-19) has been a global pandemic and caused thousands of deaths worldwide. So far, although some studies suggested some medications may be helpful, there is no effective treatment for COVID-19. It is critical to find important risk factors that affects the recovery or severity of COVID-19 and guide the treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this study, we recruited these discharged patients with COVID-19 from hospitals. We collected clinical data and analyzed the time from disease onset to the positive-to-negative transmission (TPNT) of nucleic acid tests and its related clinical variables. TPNT was considered as an important indicator for the recovery of COVID-19 patients from SARS-CoV-2 infection. COVID-19 patients were divided into short TPNT group and long TPNT group. There were significant differences on hypertension, abidol treatment, serum alanine aminotransferase (ALT), lymphocyte counts, and serum triglyceride (TG) between two groups (P<0.05). Patients in low TPNT group had higher serum triglyceride and less proportion of hypertension. Further logistic regression analysis showed that TPNT was highly associated with serum TG level and hypertension that were related to the expression of ACE2, the targeting protein for the invasion of SARS-CoV-2. Therefore, our findings demonstrate that serum triglyceride level and hypertension were important influencing factors for the recovery from SARS-CoV-2 infection. Therefore, diet changes and antihypertensive medications can be translational to the treatment of COVID-19 and promote the recovery of COVID-19 patients.