Potential mobilization of mcr-10 by an integrative mobile element via site-specific recombination in Cronobacter sakazakii.

mcr-10 is a newly-identified plasmid-borne colistin resistance gene but its mobilization mechanism remains unclear. In this study, mcr-10 was found on an IncFIB plasmid carrying virulence genes mrkABCDFJ, iucABCD/iutA and eitCBAD in a Cronobacter sakazakii By comparing with closely-related plasmids, two recombination sites were identified flanking the genetic element containing mcr-10 and an integrase-encoding gene, suggesting that site-specific recombination mediated by an integrase of an integrative mobile element is a potential mechanism for mobilizing mcr-10.