Robustness Screen in Enantioselective Catalysis Enabled Generation of Enantioenriched Heterocyclic Scaffolds in One Pot.

The reaction of aminoaromatics, e.g. (I) and (VI), with up to five alkynols, such as (II) and (III), in one pot affords mixtures of the corresponding enantioenriched aza-heterocyclic scaffolds (IV)/(V) and (VII)/(VIII) in good yields and enantioselectivities.