The genetic contribution of CTLA‐4 dimorphisms in promoter and exon 1 regions in Japanese patients with rheumatoid arthritis

Rheumatoid arthritis (RA) is a well‐known autoimmune disease, but its aetiology remains obscure. Cytotoxic T lymphocyte associated‐4 (CTLA‐4) on T cells is thought to terminate the immune response ...