Gastro retentive film of famotidine using bio-material extracted from Sapindus mukrossi fruit pulp

The   present   work  was   based   on  the   development  and   characterization   of   gastro   retentive dosage  form  appropriate   for   controlled   release  of   Famotidine,   a  drug  with  narrow  therapeutic  window. The drug loaded polymer film   of   biological   macromolecules (Sapindus mukrossi) was folded into hard gelatin capsules.  The   polymeric   film   revealed  a  fast release during  the first   hour  followed  by  a  more  gradual   drug  release  during  a  12-h  period  following   a  non-Fickian diffusion  process. Tensile strength of   polymeric film   was optimized using different amount (0.2–0.7 ml) of polyethylene glycol (PEG 400).  Various physical parameters were studied for evaluating their performance as a gastroretentive dosage form. Drug and polymers were found   to be compatible as revealed by interaction study and scanning electron microscopy (SEM) study revealed uniform dispersion of Famotidine in   polymeric matrices. The results indicate that gastro retentive film drug delivery system holds lots of potential for drug having stability problems in alkaline pH or are which mainly absorbed in acidic pH.