Observation of Internal Distribution Behavior of Micro/Nano-Sized Ceramics and Metal Particles in Mice

The internal distribution behavior of micro/nanosized ceramics and metal particles administered into the tail vein of mice was determined using magnetic resonance imaging, scanning X-ray analytical microscopy and inductively coupled plasma-atomic emission spectroscopy. After administration through the tail vein of mice, the particles circulated by blood flow reached and then remained temporarily in certain organs. In this study, we determined that the distribution behaviors in body depend upon the chemical species and the size of the particles.