Continuous Optimal CPP Based on Minute-by-Minute Monitoring Data: A Study of a Pediatric Population

This paper describes the use of minute-by-minute monitoring data to determine continuous optimal cerebral perfusion pressure (CPP) recommendations based on the autoregulatory status of pediatric patients with traumatic brain injury. Data from 79 children were retrospectively studied. Optimal CPP recommendations were obtained for the majority of the first 72 h of monitoring time. Actual CPP close to recommended CPP values was significantly associated with better outcome and was a significant independent predictor of better outcome when considering IMPACT model covariates in multivariate logistic regression.