Metastatic ovarian adenocarcinoma in a dog treated with ovariohysterectomy and intracavitary chemotherapy

1)Division of Animal Medical Research, Hassen-kai, 2–27 Onozaki, Saito-shi, Miyazaki 881-0012, 2)Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Miyazaki 889-2155, Japan. SUMMARY: A 10-year-old female Shih-Tzu presented with severe ascites and pleural effusion. Exploratory laparotomy revealed a bilateral ovarian mass and ovariohysterectomy was performed. Histopathologically, a diagnosis of ovarian papillary adenocarcinoma with peritoneal metastasis was made. The abdominal and pleural effusions both resolved after surgery but recurred 9 months later. Histopathological examination of the peritoneum and pleura indicated tumor recurrence. Intracavitary cisplatin chemotherapy led to 4-month resolution of the effusion, after which the disease progressed with no favorable response to chemothrapies. The dog died 23 months after the first surgery.