Воздействие протеиназы Aspergillus fumigatus на белки плазмы крови

Extracellular proteinase of the opportunistic Aspergillus fumigatus D-1 strain (molecular weight ~ 33 kDa, pI 4.6) was isolated. It has been shown that proteinase hydrolyzes casein, fibrin, fibrinogen, albumin, and hemoglobin to varying degrees. However, proteolytic activity in relation to globular proteins of blood plasma was comparable to fibrinolytic activity. Proteinase did not coagulate human fibrinogen, bovine fibrinogen, and also did not coagulate human and rabbit blood plasma without dilution and twice diluted. A plasminogen activating activity of A. fumigatus D-1 extracellular proteinase was found, which may indicate its ability to indirect fibrinolysis.