Thienyl, furyl, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate endothelin activity.

DESCRIBED THIENYL - furyl ROCEDURES to modulate or alter the activity of FAMILY peptide endothelin. SPECIFICALLY DESCRIBED N (isoxazolyl) TIENILSULFONAMIDAS, NYN TILIZAN FOR THESE SULPHONAMIDES inhibit the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide. ALSO DESCRIBED PROCEDURES FOR DEALING endothelin-mediated disorders by administering effective amounts ONE OR MORE OF THESE sulfonamides, or prodrug thereof, that inhibit or increase the activity of endothelin.