Optimized microorganisms straps for nadph consumer biosynthesis routes.

Microorganism strain, characterized in that it comprises the limitation of one or more activity (s) that oxidize NADPH by deletion of one or more gene (s) encoding a quinone oxidoreductase and / or a soluble transhydrogenase, and also that it comprises modifications that favor one or more enzymatic activity (s) that reduce NADP + by deleting one or more gene (s) that code for a phosphoglucose isomerase and / or a phosphofructokinase.