Propofol Wada test in the application of preoperative evaluation in patients with functional cortex lesions

Objective To investigate the application value of propofol Wada test in the application of preoperative evaluation in patients with functional cortex lesions.Methods Twenty-five patients involving the lesions in the eloquent areas underwent preoperative evaluation with propofol wada test.Twenty-three patients with epilepsy were injected via internal carotid artery.The language,memory,and motor function of the 23 patients on the contralateral hemispheres were evaluate during the hemisphere injection of anesthesia using internal carotid artery injection,and their adverse effect reactions were observed.Two patients with cerebral arteriovenous malformations in the eloquent areas were super-selectively injected propofol using nidus feeding artery.Whether they had hemiplegia or not was observed after injection in order to determine whether to conduct feeding artery embolization.Results Twenty-three patients with epilepsy completed language dominant hemisphere and motor function tests,17 of them completed memory function tests on the ipsilateral hemispheres,and 13 completed dominant hemisphere tests.Seven malformation feeding artery super-selective injections were performed in 2 patients with cerebral arteriovenous malformations before intervention.Embolization was performed after the motor function assessment was normal.The limb motor function was normal after procedure.In the internal carotid artery injections,the eye irritation symptom dominated adverse reactions occurred,some patients had transient confusion and limb muscle tension increased.Although they did not affect language and motor function tests,they affected memory function tests.Conclusions Although the propofol wada test has a certain degree of adverse reactions,it still has a higher application value in preoperative evaluation in patients with functional cortex lesions Key words: Propofol;  Injections, Intra-Arterial;  Epilepsy;  Intracranial Arteriovenous Malformations; Memory;  Speech;  Functional Laterality