Seasonal changes in antibiotics, antidepressants/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant.

Abstract Seasonal changes in the concentration of 21 pharmaceuticals in a wastewater treatment plant (WWTP) in Ceske Budějovice were investigated over 12 months. The target compounds were 10 antibiotics, 4 antidepressants, 3 psychiatric drugs, 2 antihistamines and 2 lipid regulators. 272 Wastewater samples (136 influents and 136 effluents) were collected from March 2011 to February 2012 and analyzed using two-dimensional liquid chromatography coupled with tandem mass spectrometry. All studied pharmaceuticals were frequently detected in both the influent and the effluent wastewater samples, except for meclozine, which was only found in the influent. The mean concentration of pharmaceuticals varied from 0.006 μg L −1 to 1.48 μg L −1 in the influent and from 0.003 μg L −1 to 0.93 μg L −1 in the effluent. The concentration of most pharmaceuticals was higher during winter.