Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation

ABSTRACTStearoyl lysophosphatidylcholine (LPC) exerts protective effect during endotoxemia and in experimental sepsis, but the underlying mechanism is unclear. Here, we demonstrated that stearoyl LPC could block caspase-11-mediated macrophage pyroptosis. In vitro, stearoyl LPC significantly decrease