The attenuation of postprandial lipemia by aerobic exercise depends on allelic variations of the Apolipoprotein B gene

Summary Objectives To investigate the effect of aerobic exercise on postprandial lipemia (PPL) related to allelic variants of the apolipoprotein B (APOB) gene. Methods All volunteers participated in three randomly selected trials, with at least 48 h between sessions: control (no exercise), MOD-EX (moderate exercise) and INT-EX (intense exercise). Two groups of healthy young men composed of 11 and 19 carriers of the C/C and T/C genotypes of the APOB gene (rs693) were constituted. Each exercise test (MOD-EX and INT-EX) were done until the 500-kcal expenditure and were completed 30-min before ingestion of a high-fat meal (HFM). Venous blood was collected before the exercise test and at 1, 2, 3 and 4 h after the HFM. PPL was assessed using the area under the curve approach as well as the kinetic profile of mean lipid variables. Statistical significance was adopted at P  Results The C/C group exhibited a decrease in plasma triglycerides, total cholesterol and very low-density lipoprotein levels following both MOD-EX (1378 ± 787 vs 1069 ± 537; 837 ± 122 vs 830 ± 150; 206 ± 78 vs 186 ± 59, respectively) and INT-EX (1378 ± 787 vs 1119 ± 526; 837 ± 122 vs 828 ± 151; 206 ± 78 vs 174 ± 93, respectively). Interestingly, the T/C group was insensitive to any of the attempts to reduce circulating fat. Moderate and intense aerobic exercise were both equally effective in attenuating PPL in the C/C carriers of the APOB gene.