Цистатин с как маркер нефротоксичности циклоспорина а у детей с нефротическим синдромом

The use of cystatin С as a probable marker of renal toxicity of cyclosporine A in children with nephritic syndrome, treated with this medication for a long time, is the subject of an interest. The present study included 29 children treated with cyclosporine A, divided into 3 groups depending on the duration of treatment ( 2 years). The increase of cystatin С level in these groups compared with cystatin С level in control group (10 children without diseases of kidney) was marked. The highest level of cystatin С was detected in children treated with therapeutic doses of cyclosporine A (3-5 mg/kg daily) over 1 year. Authors showed positive correlation between cystatin С level in serum and medication's dose