Effect of Triterpenoid Saponins from Bacopa monniera on Scopolamine-Induced Memory Impairment in Mice

Three new saponins, bacopasides IX−XI ( 1- 3), together with their known analogues bacopaside I ( 4), bacopaside II ( 5), bacopasaponsin C ( 6), and bacopasaponsin D ( 7), were isolated from the whole plant of BACOPA MONNIERA. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice.