INTERACTION BETWEEN AIR POLLUTION AND BMI OVER LUNG FUNCTION AND EXHALED NITRIC OXIDE IN A COHORT OF ADOLESCENTS OBESE IN MEXICO CITY

Background and Aim. Both, obesity and asthma are common conditions. Air pollution has been associated with decreased lung function and higher inflammation. The combined effect of weight loss and air pollution on lung function and inflammation had not been evaluated. We conducted a study to evaluate the effect of air pollution and weight-loss on lung function and airway inflammation in obese adolescents with and without asthma. Methods: We studied a cohort of 121 asthmatic and 226 non-asthmatic adolescents with obesity, followed by 12 months average during a weight loss intervention program. Spirometric tests and measurements of FeNO were conducted each month during follow-up. Exposure was estimated from outdoor PM2.5, concentrations recorded by the Mexico City government at fixed-site central monitoring (RAMA). Data were analyzed using linear mixed effects models. Results: PM2.5 concentrations ranged 4.6 to 56.8 •g/m3 during study period (mean=25.8 ug/m3). Mean BMI (kg/m2) decreased from 30.2(SD=4.8) to 2...