Synthesis of Ciprofloxacin Drug Capped Silver Nanoparticles and Their Antimicrobial Activity: A Joint Spectrophotometric and Density Functional Investigation

Ciprofloxacin drug caped silver nanoparticles (Cp-AgNPs) have been produced via fast, economical and one-pot synthesis method for the first time. An amply consumed antibacterial drug ciprofloxacin (Cp) has been employed as the stabilizing agent for the AgNPs at biologically relevant conditions. Several spectrophotometric measurements, transmission electron microscopy (TEM), dynamic light scattering (DLS) measurements, theoretical studies using density functional theory (DFT) and antibacterial activity studies have been utilized for the physico-chemical characterization of the Cp-AgNPs assembly systems to justify their efficiency as potential therapeutics against antibacterial infection. The Cp-AgNPs assembly has been utilized for antibacterial activity studies involving Escherichia colii bacterial strain. Dose dependent studies showed that, decreasing drug concentration using Cp-AgNPs would retain its efficacy successfully. Absence of any hazardous chemical in the whole process of synthesis and their therapeutic efficacy will definitely make these Cp-AgNPs assembly system to act as an effective therapeutic agent to treat bacterial infection.