Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies

Erik Sjögren,Magnus M. Halldin,O. Stålberg,Anna K. Sundgren-Andersson

Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies

2018

Erik Sjögren
Magnus M. Halldin
O. Stålberg
Anna K. Sundgren-Andersson

BackgroundThe transient receptor potential vanilloid receptor 1 (TRPV1) is a nonselective cation channel involved in the mediation of peripheral pain to the central nervous system. As such, the TRP ...

Keywords:

TRPV1
Anesthesia
Transient receptor potential channel
MicroDose
Medicine
Analgesic
Pharmaceutical sciences
Capsaicin
Dorsal root ganglion
Pharmacology
In vivo
Drug development
Chinese hamster ovary cell
Drug metabolism

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