Microneedle device and manufacturing method thereof

A substrate, disposed on the substrate, and microneedle, a microneedle device and a bioactive composition adhered onto the microneedles and / or substrate, the physiologically active composition , glycerin, ethylene glycol, propylene glycol and 1,3 and at least one polyhydric alcohol butylene selected from glycol, and a physiologically active substance, a microneedle device which is substantially free of water.