exercise as a buttress against parkinsons disease

The integrity of the nigrostriatal dopaminergic system underpins the capacity to initiate and control movement with loss of dopamine a central aspect of inability to express activity. Effective strategies for enhancing physical exercise provide both preventional and interventional ingredients for maintaining movement and/or reinstating movement among patients with Parkinson’s disease, as well as improving the performance of non-motor behaviors. The relative loss or availability of striatal dopamine correlates directly with the expression of locomotor behavior in mice. Regular and persistent maintenance of exercise programs ensures a plethora of lasting benefits that include enhanced or repaired functional connectivity, and elevations of mood, cognitive performance, sleep quality and motor ability concurrent with reductions in pain, apathy and weight problems. Keywords: Motor; Dopamine; Exercise; Activity; Intervention; Prevention; Performance.