Histotripsy combined with catheter-directed thrombolytics for clot disintegration in vitro

Histotripsy is a focused ultrasound therapy under development as an adjuvant to lytic therapy for the treatment of deep vein thrombosis. In this study, we investigate the mechanisms of clot disintegration (e.g., hemolysis and thrombolysis) under the action of histotripsy and catheter-directed thrombolytics, and demonstrate that this combination significantly reduces the threshold lytic dose required for effective thrombolysis.