Synthesis of novel 2-mercapto-4-(p-aminophenyl sulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide derivatives via the Biginelli reaction
2014
Series of 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide Aa-h were synthesized via the biginelli condensation. 2-mercapto-4-amino-6-(aryl)-pyrimidine-5carboxamide react with p-acetamidophenylsulphonylchloride in the presence of pyridine 2 to form 2mercapto-4-(p-acetamidophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide 3. It was treated with diluted HCl under reflux afforded 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)pyrimidine-5-carboxamide Aa-h. . The newly synthesized compounds were characterized by elemental analyses, infrared (IR), 1 H NMR and 13 C NMR spectroscopic investigation.
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