Sleep Disruption and Objective Sleepiness in Children With β-Thalassemia and Congenital Dyserythropoietic Anemia

Background Sleep fragmentation and periodic leg movement syndrome (PLMS) have been reported in adults with iron deficiency anemia. Little is known about sleep function and daytime sleepiness in children with chronic anemia such as β-thalassemia or congenital dyserythropoietic anemia type 1 (CDA-1). Objectives To investigate if children and adolescents who have β-thalassemia (major or intermedia) or CDA-1 experience sleep fragmentation and objective daytime sleepiness and also to investigate if children and adolescents with β-thalassemia have obstructive sleep apnea. Methods Ten patients (7 males and 3 females) with β-thalassemia (mean [SD] age, 10.4 [7.3] years), 10 patients (7 males and 3 females) with CDA-1 (mean [SD] age, 13.5 [5.1] years), and 13 healthy volunteer control children(7 males and 6 females) (mean [SD] age, 10 [4] years) underwent nocturnal polysomnographic studies. A multiple sleep latency test was performed for 6 patients who had β-thalassemia and 8 patients who had CDA-1. Results Both patient groups, that is, those who had β-thalassemia and those who had CDA-1, had multiple arousals during sleep (mean [SD], 27.8 [11.4] events per hour and 23.8 [11.8] events per hour, respectively) compared with the control subjects (12.1 [6.6] events per hour) ( P Conclusion Children and adolescents with β-thalassemia or CDA-1 have evidence of impaired sleep function that is partially due to periodic limb movements during sleep and arousals that result in objective diurnal sleepiness.