Surgical, pharmacological, radiological and combined treatment of pituitary adenomas

creting PA (even in giant) we treat it by dopamine-agonist. Somatostatin-analogues we use in GH-tumors like pre-operative treatment and in some cases after surgery. In cases of partial removal (particularly in hormonal active tumors), recurrence, or tumors with high mitotic activity (Ki-67 >3%), nuclear polymorphism we use post-op stereotactic radiotherapy. Gamma knife and LINAC like a first-step we use very rare. We regularly follow-up most of our patients for tumor control and adequate hormonal correction. Conclusion: The optimal treatment choice (surgery, pharmacotherapy, radiotherapy or combined treatment) could be taken commonly by neurosurgeon, endocrinologist and radiologist. Further improvement of PA treatment depends on either surgical technique development or modern pharmacological and radiological methods evolution.