Chronic exposure to dibromoacetic acid, a water disinfection byproduct, diminishes primordial follicle populations in the rabbit

Haloacetic acids are formed during the process of water disinfection when chlorinated or brominated products used to disinfect water react with organics and bromine in source water. By weight, haloacetic acids are among the most abundant water disinfection byproducts and are a prominent concern from a health and regulatory standpoint (Uden and Miller, 1983). Certain haloacetic acids, including dibromoacetic acid (DBA), have been shown to cause adverse reproductive and developmental effects in laboratory animals. Testicular toxicity following acute exposure to DBA (10 to 1250 mg/kg/day via po gavage for 1 to 14 days) has been demonstrated in adult male rats with marked