29 MALE ADOLESCENTS WITH CONSTITUTIONAL DELAY OF GROWTH AND PUBERTY|[period]| THERAPEUTICAL EFFECT OF TESTOSTERONE

Constitutional delay of grewth and puberty (CDGP) is characterized by small stature and delay of bone age (BA) and sexual development. In order to accelerate growth velocity (GV) and sexual development 23 boys with CDGP who ware worried for their poor growth and pubertal development were treated with monthly intramuscular testosterone injections (41+7.7 mg/m2) during 18 months (T). Thirteen boys with CDGP who ware not treated served as control group (C). Before treatment there were no differences between groups in chronological age (CA) T:14.65+0.9 vs C:14.31+0.8 (p=NS), SDS of height (SDS) T:−3.30+0.81 vs C:−2.85+0.62 (p=NS), SDS of height for BA (SDSBA) T:−0.24+0.9 vs −0.04+0.4 (p=NS), BA T: 11.81+1.1 vs 11.59+1.1 (p=NS), pubic hair (Tanner) (P) T:1.82+0.7 vs. 1.88+0.6 (p=NS), testicular volume (TV) T.7.0+2.6 vs 6.8+2.1 (p=NS) nor GV T:4.01+1.3 vs 4.9+1.4 (p=NS). Patients were clinically evaluate approximately every 3.5 months. In response to treatment we obtained the following auxological data: